When Vampirella assumes her new role as Queen of the Nosferatu, she inherits a membership into The Kabal, a clandestine organization of witches, werewolves, vampires, and other supernatural creatures. Sworn to protect the status quo of their shadow world, The Kabal hunts down and neutralizes renegade monsters and fanatical cultists before they can trigger the Apocalypse. As a strange rabies-like plague spreads through the slums of Sao Paolo, infecting its victims with homicidal fury, Vampirella races off in pursuit of Dr. Faustus, the creator of the disease. But the mad scientist is only one part in a global plot of destruction, and his fellow conspirators are perhaps too long-lived and powerful to defeat!